p53 Tumour Suppressor Genes Activated By Herbs and Supplements

Cells are incessantly bombarded by an assortment of environmental and intrinsic factors that cause cellular damage. Although mild damage is often reparable, extensive damage poses a potential oncogenic danger. In the latter case, the benefit of the organism calls for the eradication of the potentially life-threatening cells, which often is achieved through activation of an apoptotic cell death program. Thus, the cell is continually faced with an agonizing choice: repair and live, or die (Aylon & Oren 2007).
Mutations of p53, a tumor suppressor gene, are known to be involved in the pathogenesis of a number of neoplasms. Findings support the hypothesis that p53 mutations are homogeneous throughout a tumor and may thus be a more useful diagnostic and prognostic indicator than the expression of p53, which does not reliably correlate with p53 mutations.
P53 has many anticancer mechanisms, and plays a role in apoptosis, genetic stability, and inhibition of angiogenesis. In its anti-cancer role, p53 works through several mechanisms:
1. It can activate DNA repair proteins when DNA has sustained damage.
2. It can induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition (if it holds the cell here for long enough, the DNA repair proteins will have time to fix the damage and the cell will be allowed to continue the cell cycle).
3. It can initiate apoptosis, the programmed cell death, if DNA damage proves to be irreparable.
Scutellaria barbata, a traditional Chinese herbal medicine native to southern China, is widely used as an anti-inflammatory and a diuretic in China. Extracts of Scutellaria barbata have been shown to have in vivo growth inhibitory effects on a number of cancers such as S180 mouse sarcoma, U14 cervical carcinoma, solid hepatoma, etc. The extract of Scutellaria barbata on human lung cancer cells, A549, exhibited a marked growth inhibitory effect in a dose-dependent manner. The IC50 was approximately 0.21 + 0.04 mg/ml.
Apoptosis of A549 cells induced by Scutellaria barbata was analyzed by Annexin-V staining and demonstrated that treated cells with 0.5 mg/ml Scutellaria barbata extract for 48 hours resulted in a rate of cell apoptosis of 57.67%. The cDNA microarray experiment was performed to characterize the mechanism of Scutellaria barbata induced killing and found that two genes related to cell response to DNA damage, GADD45A and GIP, decreased dramatically. A total of 20 cell cycle genes were found to have changed after treatment indicated that the cell cycle was widely involved in the Scutellaria barbata treatment. Some enzyme activity (STK12,DUSP5 and TOPK), cell signal transduction (GIP, BMP2), nucleic acid binding (ATF3,HNRPD and SMARCF1)were also found to be affected (Yin et al 2004).
Herba Scutellaria barbatae, was cytotoxic to 100% (11 of 11) of actively proliferating ovarian lines tested and 50% (2 of 4) of actively proliferating breast cell lines tested. Confluent cultures were resistant to killing by herb, whereas subconfluent cultures were sensitive. Resistant proliferating cell lines expressed higher levels of bcl2 (Powell et al 2003).

You can leave a response, or trackback from your own site.

30 Responses to “p53 Tumour Suppressor Genes Activated By Herbs and Supplements”

  1. Meso101.com – Mesothelioma Resources and Information…

    […]p53 Tumour Suppressor Genes Activated By Herbs and Supplements | ASSOCIATION OF INTEGRATIVE ONCOLOGY AND CHINESE MEDICINE(AIOCM)[…]…

  2. Jane Williams…

    […]p53 Tumour Suppressor Genes Activated By Herbs and Supplements | ASSOCIATION OF INTEGRATIVE ONCOLOGY AND CHINESE MEDICINE(AIOCM)[…]…

  3. You made some decent points there. I looked on the internet for the issue and found most individuals will go along with with your website.

  4. Thanks , I have recently been searching for information approximately this topic for a while and yours is the best I have discovered so far. But, what in regards to the conclusion? Are you positive about the source?|What i do not realize is in reality how you are no longer actually a lot more smartly-preferred than you may be now. You’re so intelligent.

  5. Wow! This might be one particular of the most valuable blogs Weve ever arrive across on this topic. Basically Good. I’m also a specialist in this subject so I can understand your effort.

  6. Okay, very good article plus fair feedback from your visitors, I have saved this web page on a handful of social book-marking web sites because it’s a fantastic read, thanks a lot.

  7. Thanks for another great article. Where else could anybody get that type of info in such an ideal manner of writing? I’ve a presentation next week, and I am at the look for such information.

  8. I wanted to thank you for this interesting I definitely loved every little bit of it. I have you bookmarked your web site to look at the latest stuff you post.

  9. A thoughtful opinion and ideas I will use on my website. You’ve obviously spent some time on this. Thank you!

  10. Cool Webpage. I am going to remember to check back very often.

  11. Another great post! Really can’t wait for more!

  12. Mandy Ijames says:

    It’s fairly demanding to find posts like these since there is absolutely not much description made available on the web. Thanks.

  13. You actually make it appear so easy together with your presentation however I in finding this matter to be really something which I believe I’d by no means understand. It seems too complex and extremely huge for me. I’m looking forward on your next post, I’ll try to get the cling of it!

  14. I just wanted to leave a quick comment. Many thanks for making the effort to write this, I enjoyed reading through it. Have a superb day.

  15. I just like the helpful information you provide to your articles. I will bookmark your blog and check once more right here regularly. I am quite certain I’ll be told lots of new stuff proper here! Best of luck for the next!

  16. Why is it that the most frequent posts I view on blog sites are like “Wow this is genuinely spectacular content?” I indicate the majority of the stuff that I locate is truly good but I merely imagine that its odd for individuals to express that over and over. I desire to read articles that are truly informative and have a little something to give. A lot of sites are unquestionably very good if you can easily get your head around the composition.

  17. Chicken Coop says:

    Attractive section of content. I just stumbled upon your site and in accession capital to assert that I get in fact enjoyed account your blog posts. Anyway I will be subscribing to your augment and even I achievement you access consistently fast.

  18. hi!,I love your writing so so much! percentage we keep up a correspondence more about your article on AOL? I need an expert on this space to solve my problem. May be that is you! Looking ahead to look you.

  19. Samara Krolikowski
    Hey there! I’ve been following your site for a while now and finally got the courage to go ahead and give you a shout out from Atascocita Tx! Just wanted to mention keep up the good work!

  20. Why is it that the most frequent articles I see on blog sites resemble “Wow this is genuinely fantastic material?” I mean most of the stuff that I find happens to be actually good however I merely imagine that its odd for individuals to say that over and over. I just like to read articles that happen to be actually useful as well as have something to give. A lot of websites happen to be unquestionably great if you can receive your head around the content.

  21. click here says:

    kitchen tiles
    A person essentially help to make seriously articles I would state. This is the first time I frequented your web page and thus far? I surprised with the research you made to make this particular publish amazing. Great job! backsplash

  22. okuma reels says:

    “Wow this happens to be truly fantastic material?” I indicate the majority of the stuff that I discover is truly good but I merely think that its odd for individuals to say that over and over. I desire to read posts that are truly interesting and have a little something to furnish.

  23. “Wow this is truly awesome content?” I suggest the majority of the stuff that I discover is genuinely very good however I simply imagine that its weird for individuals to express that over and over. I just like to check out articles that are genuinely interesting as well as have a little something to offer.

  24. I just like to read articles that are genuinely useful as well as have a little something to give. Most websites are truly good if you can easily get your head around the subject matter.

  25. Vincent says:

    Thanks – real great info.

  26. Definitely this blog is very informative and neatly designed.

  27. check it says:

    We recognize all of the feedback and info we have actually obtained from the users of this website. We are going to continue to follow the subject matters here and intend extend the identical quantity of valued information.

  28. Tremendous piece you’ve produced here! The internet is filled with horrid penning and I was grabbed by your limpidity. Your decisions are precise and I’ll straightaway subscribe to your rss feed to remain up to date together together with your up emerging postings. Yes! I admit it, your composition style is unbelievable and that i work more concentrated on mine.

Leave a Reply

You must be logged in to post a comment.